Heyns A D, Lötter M G, Badenhorst P N, Minnaar P C, Vorster B J, Retief F P
S Afr Med J. 1979 Aug 11;56(6):229-33.
A 34-year old woman presented with the clinical and laboratory features of thrombotic thrombocytopenic purpura (TTP). Studies with isologous platelets labelled with 111In-oxine revealed a short half-life of circulating platelets (18,5 hours) and destruction of the transfused platelets in the spleen, liver and bone marrow. There was no scientigraphic evidence of deposition of labelled platelets in the vasculature. The patient was treated with daily fresh frozen plasma transfusions, but no improvement in platelet count or serum urea level was noted. Although there was no clinical evidence of a bleeding tendency at the time, the patient had a fatal cerebrovascular haemorrhage. The findings in this case suggest that an immune type destruction of platelets may occur in TTP.
一名34岁女性表现出血栓性血小板减少性紫癜（TTP）的临床和实验室特征。对用111铟-奥克辛标记的同源血小板进行的研究显示，循环血小板的半衰期较短（18.5小时），且输注的血小板在脾脏、肝脏和骨髓中被破坏。没有放射性显像证据表明标记血小板在脉管系统中沉积。该患者接受了每日新鲜冰冻血浆输注治疗，但血小板计数或血清尿素水平未见改善。尽管当时没有出血倾向的临床证据，但该患者发生了致命的脑血管出血。该病例的研究结果表明，TTP可能发生血小板的免疫性破坏。
