Drewinko B, Loo T L, Brown B, Gottlieb J A, Freireich E J
Cancer Biochem Biophys. 1976 May;1(4):187-95.
Adriamycin was paired with 12 other chemotherapeutic drugs in a search for possible synergistic pairs. Cell lethality was investigated by the colony-formation method utilizing a long-term human lymphoma cell line. Addative effects were noted with CCNU, ara-C, prednisolone, DDP, VP-16, and Yoshi, and mild synergistic effects with BLEO and CS. Adriamycin reduced the killing ability of BCNU and MeCCNU when applied simultaneously. This antagonistic effect was canceled by sequential incubation with each drug. It appears that no significant synergism can be expected by simultaneous pairing of adriamycin with some currently available chemotherapeutic agents.
阿霉素与其他12种化疗药物配对，以寻找可能的协同组合。利用一种长期培养的人类淋巴瘤细胞系，通过集落形成法研究细胞杀伤力。观察到与环己亚硝脲、阿糖胞苷、泼尼松龙、顺铂、依托泊苷和优福定有相加作用，与博来霉素和环磷酰胺有轻度协同作用。同时应用时，阿霉素会降低卡莫司汀和甲环亚硝脲的杀伤能力。这种拮抗作用可通过每种药物的序贯孵育而消除。看来，阿霉素与一些目前可用的化疗药物同时配对，预期不会有显著的协同作用。
