Drewinko B, Green C, Loo T L
Cancer Treat Rep. 1976 Nov;60(11):1619-25.
Cis-dichlorodiammineplatinum(II) (DDP) was paired with 11 other chemotherapeutic drugs in a search for possible synergistic pairs. Cell lethality was investigated by the colony-formation technique utilizing a long-term culture of human lymphoma cells. Synergistic effects were noted for pair combinations with all alkylating agents, bleomycin, adriamycin, camptothecin, and cytosine arabinoside. Additive effects were recorded for combinations with prednisolone and VP-16-213, while DDP reduced the capacity of cells to absorb sublethal damage induced by alkylating agents.
顺二氯二氨铂（II）（DDP）与其他11种化疗药物配对，以寻找可能的协同组合。利用人淋巴瘤细胞的长期培养，通过集落形成技术研究细胞杀伤力。发现与所有烷化剂、博来霉素、阿霉素、喜树碱和阿糖胞苷的配对组合具有协同作用。与泼尼松龙和依托泊苷的组合记录为相加作用，而DDP降低了细胞吸收烷化剂诱导的亚致死损伤的能力。
