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Although (-)-hyoscine has been in clinical use for many years, there is little detailed information concerning the speed of absorption or duration of action of the drug after single intramuscular doses.2. The time course of action of the drug was therefore examined using biological methods, and measurements were made of saliva flow, pulse rate, pupil diameter and mental alertness for up to 8 hr after doses of 0.4, 0.2, 0.1 and 0.05 mg of the hydrobromide.3. These techniques gave comparable results and peak activity was achieved at 1-2 hr after dose and followed by a gradual decline over the 8 hr period.4. The results are compared with those of earlier experiments of a similar kind, and discussed in relation to their bearing on both therapeutics and experimental design.

尽管（-）-东莨菪碱已临床应用多年，但关于单次肌内注射后该药物的吸收速度或作用持续时间，几乎没有详细信息。
因此，采用生物学方法研究了该药物的作用时间进程，并在给予0.4、0.2、0.1和0.05毫克氢溴酸盐后长达8小时内，对唾液分泌量、脉搏率、瞳孔直径和精神警觉性进行了测量。
这些技术得出了可比的结果，给药后1至2小时达到活性峰值，随后在8小时内逐渐下降。
将结果与早期类似实验的结果进行了比较，并就其对治疗学和实验设计的影响进行了讨论。

Although (-)-hyoscine has been in clinical use for many years, there is little detailed information concerning the speed of absorption or duration of action of the drug after single intramuscular doses.2. The time course of action of the drug was therefore examined using biological methods, and measurements were made of saliva flow, pulse rate, pupil diameter and mental alertness for up to 8 hr after doses of 0.4, 0.2, 0.1 and 0.05 mg of the hydrobromide.3. These techniques gave comparable results and peak activity was achieved at 1-2 hr after dose and followed by a gradual decline over the 8 hr period.4. The results are compared with those of earlier experiments of a similar kind, and discussed in relation to their bearing on both therapeutics and experimental design.

尽管（-）-东莨菪碱已临床应用多年，但关于单次肌内注射后该药物的吸收速度或作用持续时间，几乎没有详细信息。
因此，采用生物学方法研究了该药物的作用时间进程，并在给予0.4、0.2、0.1和0.05毫克氢溴酸盐后长达8小时内，对唾液分泌量、脉搏率、瞳孔直径和精神警觉性进行了测量。
这些技术得出了可比的结果，给药后1至2小时达到活性峰值，随后在8小时内逐渐下降。
将结果与早期类似实验的结果进行了比较，并就其对治疗学和实验设计的影响进行了讨论。

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