实验性镇痛剂肾病中的乳头坏死
Papillary necrosis in experimental analgesic nephropathy.
作者信息
Saker B M, Kincaid-Smith P
出版信息
Br Med J. 1969 Jan 18;1(5637):161-2. doi: 10.1136/bmj.1.5637.161.
Abstract
A proprietary aspirin, phenacetin, and caffeine preparation given to rats in a dose equivalent to that taken by patients with analgesic nephropathy produced papillary necrosis in 55%. There was a higher incidence in rats deprived of fluids overnight.Papillary necrosis was not noted in rats receiving twice as much phenacetin.These findings support the argument that phenacetin should not be singled out as the substance responsible for analgesic nephropathy in man.
摘要
一种含阿司匹林、非那西丁和咖啡因的专利制剂，以相当于镇痛性肾病患者服用的剂量给予大鼠，55%的大鼠出现了乳头坏死。在夜间禁水的大鼠中发病率更高。服用两倍剂量非那西丁的大鼠未出现乳头坏死。这些发现支持了不应将非那西丁单独列为人类镇痛性肾病病因的观点。
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