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源自犬肾的细胞系（MDCK）的分泌活性和致癌性。

Secretory activity and oncogenicity of a cell line (MDCK) derived from canine kidney.

作者信息

Leighton J, Brada Z, Estes L W, Justh G

出版信息

Science. 1969 Jan 31;163(3866):472-3. doi: 10.1126/science.163.3866.472.

DOI:10.1126/science.163.3866.472
PMID:5762397
Abstract

A cell line (MDCK) of dog kidney origin grows on a glass surface as a mosaic of epithelium with many multicellular hemispherical vesicles. The cells lining the blisters actively secrete into the cyst cavities. Suspensions of these cells injected intravenously in the chick embryo produce brain metastases resembling adenocarcinoma.

摘要

一种源自犬肾的细胞系（MDCK）在玻璃表面生长，形成由许多多细胞半球形囊泡构成的上皮镶嵌体。水泡内衬的细胞会主动分泌到囊腔中。将这些细胞的悬浮液静脉注射到鸡胚中会产生类似于腺癌的脑转移瘤。

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Secretory activity and oncogenicity of a cell line (MDCK) derived from canine kidney.源自犬肾的细胞系（MDCK）的分泌活性和致癌性。
Science. 1969 Jan 31;163(3866):472-3. doi: 10.1126/science.163.3866.472.
2
A cell line derived from normal dog kidney (MDCK) exhibiting qualities of papillary adenocarcinoma and of renal tubular epithelium.一种源自正常犬肾的细胞系（MDCK），具有乳头状腺癌和肾小管上皮的特征。
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Cloning and assessment of tumorigenicity and oncogenicity of a Madin-Darby canine kidney (MDCK) cell line for influenza vaccine production.用于流感疫苗生产的 Madin-Darby 犬肾 (MDCK) 细胞系的克隆及其致瘤性和致癌性评估。
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Morphologic and serologic studies of transplanted human leukocyte culture (M-1) cells in laboratory animals.对实验动物体内移植的人白细胞培养物（M-1）细胞进行的形态学和血清学研究。
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Evaluation of tumorigenic potential of high yielding cloned MDCK cells for live-attenuated influenza vaccine using in vitro growth characteristics, metastatic gene expression and in vivo nude mice model.利用体外生长特性、转移基因表达及体内裸鼠模型评估高产克隆MDCK细胞用于减毒活流感疫苗的致瘤潜力。
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Clinical and experimental tumors of the kidney in tissue culture and in the chick embryo.
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Cell surface glycosaminoglycans of cell line MDCK derived from canine kidney.源自犬肾的MDCK细胞系的细胞表面糖胺聚糖
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Comparison of invasiveness and non-invasiveness of two epithelial cell lines in vitro.两种上皮细胞系在体外侵袭性与非侵袭性的比较。
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