大鼠血红蛋白三乙锡结合位点中组氨酸的证据。
Evidence for histidine in the triethyltin-binding site of rat haemoglobin.
作者信息
Rose M S
出版信息
Biochem J. 1969 Jan;111(2):129-37. doi: 10.1042/bj1110129.
Abstract
One molecule of rat haemoglobin binds two molecules of triethyltin. The binding sites are located on the globin and there is co-operativity between the sites such that the intrinsic affinity constant at pH8.0 increases from 3.5x10(5)m(-1) for the binding of the first triethyltin molecule to 5.0x10(5)m(-1) for the binding of the second. Evidence is presented, from pH studies and the kinetics of inhibition due to photo-oxidation, that each binding site contains two histidine residues.
摘要
一个大鼠血红蛋白分子能结合两个三乙基锡分子。结合位点位于珠蛋白上，且这些位点之间存在协同性，使得在pH8.0时，第一个三乙基锡分子结合的固有亲和常数为3.5×10⁵m⁻¹，而第二个三乙基锡分子结合的固有亲和常数增至5.0×10⁵m⁻¹。来自pH研究及光氧化所致抑制动力学的证据表明，每个结合位点含有两个组氨酸残基。
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1
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Adv Protein Chem. 1952;7:319-86. doi: 10.1016/s0065-3233(08)60022-4.
2
Photooxidation of amino acids in the presence of methylene blue.在亚甲蓝存在的情况下氨基酸的光氧化作用。
Arch Biochem Biophys. 1951 Aug;33(1):90-109. doi: 10.1016/0003-9861(51)90084-7.
3
The conversion of cyanogen chloride to cyanide in the presence of blood proteins and sulphydryl compounds.在血液蛋白质和巯基化合物存在的情况下，氯化氰向氰化物的转化。
Biochem J. 1951 Mar;48(3):271-6. doi: 10.1042/bj0480271.
4
Identification of amino acids involved in phosphoglucomutase action.参与磷酸葡萄糖变位酶作用的氨基酸的鉴定。
J Biol Chem. 1962 Aug;237:2493-505.
5
Trialkyltins and oxidative phosphorylation. The [32P]phosphate-adenosine triphosphate-exchange reaction.三烷基锡与氧化磷酸化。[32P]磷酸盐-三磷酸腺苷交换反应。
Biochem J. 1961 May;79(2):214-9. doi: 10.1042/bj0790214.
6
The kinetics of the urea denaturation of hemoglobin. I. Beef oxyhemoglobin.血红蛋白尿素变性的动力学。I. 牛肉氧合血红蛋白。
Biochemistry. 1962 Nov;1:1005-17. doi: 10.1021/bi00912a010.
7
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