Cwynarski M T, Saxton H M
Br Med J. 1969 Feb 22;1(5642):486. doi: 10.1136/bmj.1.5642.486.
To investigate whether urographic contrast media might precipitate Bence Jones protein in the renal tubules and lead to renal failure in patients with myelomatosis, the reaction between the media and myeloma urine was studied in vitro. Appreciable precipitation was found only in urine at or below pH 4.5, and its occurrence did not correlate with the type or concentration of protein present. It is concluded that the risk of urography in myelomatosis is very small.
为了研究尿路造影剂是否会在肾小管中沉淀本-周蛋白并导致骨髓瘤患者肾衰竭,对造影剂与骨髓瘤尿液之间的反应进行了体外研究。仅在pH值为4.5或更低的尿液中发现明显沉淀,且其发生与存在的蛋白质类型或浓度无关。结论是骨髓瘤患者进行尿路造影的风险非常小。