Gage P W, Eisenberg R S
J Gen Physiol. 1969 Mar;53(3):298-310. doi: 10.1085/jgp.53.3.298.
In frog sartorius muscle fibers in which the transverse tubular system has been disrupted by treatment with glycerol, action potentials which are unaccompanied by twitches can be recorded. These action potentials appear to be the same as those recorded in normal fibers except that the early afterpotential usually consists of a small hyperpolarization of short duration. After a train of action potentials no late afterpotential is seen even when the membrane potential is changed from the resting level. In fibers without transverse tubules hyperpolarizing currents do not produce a creep in potential. The interruption of excitation-contraction coupling, the changes in the afterpotentials, and the disappearance of creep are all attributed to the lack of a transverse tubular system.
在用甘油处理使横管系统遭到破坏的青蛙缝匠肌纤维中，可以记录到不伴有抽搐的动作电位。这些动作电位似乎与在正常纤维中记录到的动作电位相同，只是早期后电位通常由持续时间较短的小超极化组成。在一串动作电位之后，即使膜电位从静息水平改变，也看不到晚期后电位。在没有横管的纤维中，超极化电流不会产生电位蠕动。兴奋 - 收缩偶联的中断、后电位的变化以及蠕动的消失都归因于缺乏横管系统。
