Saigal S, Sinclair J C
J Pediatr. 1977 Jun;90(6):934-8. doi: 10.1016/s0022-3476(77)80562-3.
Fifteen thriving low-birth-weight infants who weighed less than 1,950 gm at birth were randomly selected to study the urine solute excretion on two milk-based proprietary formulas, SMA or Formula 4. The results showed that urine oxmolality rose progressively with increasing caloric concentration and was 78, 111, and 163 mOsm/kg H2O on 67, 80, and 100 kCal/dl SMA, respectively. Formula 4 gave rise to significantly higher urine osmolality (133 mOsm/kg H2O) than SMA, when fed at the same caloric density of 67 kCal/dl. Although the dependence of urine solute excretion on dietary load was confirmed, the rapidly growing low-birth-weight infant appears to incorporate a larger portion of potential urine solute into growing tissues, than is the case in the term infant.
随机选择了15名出生时体重低于1950克且发育良好的低体重婴儿，以研究两种以牛奶为基础的专利配方奶粉（SMA或配方4）对尿溶质排泄的影响。结果显示，尿渗透压随着热量浓度的增加而逐渐升高，在每分升含67、80和100千卡热量的SMA配方奶粉喂养下，尿渗透压分别为78、111和163毫渗量/千克水。当以相同的热量密度每分升67千卡喂养时，配方4导致的尿渗透压（133毫渗量/千克水）显著高于SMA。尽管尿溶质排泄对饮食负荷的依赖性得到了证实，但与足月儿相比，快速生长的低体重婴儿似乎将更大比例的潜在尿溶质纳入生长组织中。
