Janerich D T, Glebatis D M, Dugan J M
JAMA. 1977 May 16;237(20):2199-201.
A random selection of 1,230 upstate New York childbearing women was used to examine the history of oral contraceptive use in women with a clinical diagnosis of benign breast disease. We found that 73 women who had benign breast disease had a reduced duration of pill use. When determining the reason for this reduction, we found that in a significant portion (P less than .05) of our benign breast disease cases, the women had been advised by their physicians to discontinue pill use for breast-related reasons. We then surveyed a large group of upstate New York physicians. One third of them considered benign breast disease a potential contraindication for starting oral contraceptive use. Nearly one half throught the development of benign breast disease to be a potential contraindication for continuing oral contraceptive use. It is premature to conclude that oral contraceptive usage protects against benign breast disease.
随机选取了1230名纽约州北部的育龄妇女,以研究临床诊断为良性乳腺疾病的女性口服避孕药的使用史。我们发现,73名患有良性乳腺疾病的女性服用避孕药的时间缩短。在确定这种缩短的原因时,我们发现,在相当一部分(P小于0.05)的良性乳腺疾病病例中,这些女性的医生建议她们因乳腺相关原因停止服用避孕药。然后,我们对一大群纽约州北部的医生进行了调查。其中三分之一的医生认为良性乳腺疾病是开始使用口服避孕药的潜在禁忌症。近一半的医生认为良性乳腺疾病的发展是继续使用口服避孕药的潜在禁忌症。得出口服避孕药的使用可预防良性乳腺疾病的结论还为时过早。