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[患有肿瘤的大鼠血液和肝脏过氧化氢酶的分子异质性]

[Molecular heterogeneity of blood and liver catalase rats with tumors].

作者信息

Komov V P, Rakhmanina T F, Strelkova M A

出版信息

Vopr Onkol. 1977 Jan;23(1):49-53.

PMID:577062
Abstract

By the method of gel-chromatography on sefadex G-200 and electrophoresis in polyacrylamid gel molecular forms of blood and liver catalase were isolated in rats with transplantable Pliss lymphosarcoma. Under study were changes in microheterogeneity of the enzyme, its activity and kinetic parameters in the kinetics of tumor growth. Quantitative and qualitative changes in the parameters under investigation were found already on the second day after tumor transplantation. These changes are enhanced with tumor progression.

摘要

采用葡聚糖凝胶G - 200凝胶色谱法和聚丙烯酰胺凝胶电泳法,从可移植性Pliss淋巴肉瘤大鼠中分离出血液和肝脏过氧化氢酶的分子形式。研究了肿瘤生长动力学过程中该酶微观异质性、活性及动力学参数的变化。在肿瘤移植后第二天就已发现所研究参数的定量和定性变化。这些变化随着肿瘤进展而加剧。

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