Adamopoulos D, Vlassopoulos C, Seitanides B, Contoyiannis P, Vassilopoulos P
Acta Endocrinol (Copenh). 1977 May;85(1):198-208. doi: 10.1530/acta.0.0850198.
The effect of endogenous and exogenously administered oestrogens, androgens and progesterone on plasma and urinary uric acid and uric acid clearance was studied in a total of 65 healthy volunteers, including normal menstruating and post-menopausal women, girls with primary amenorrhoea and adult male subjects. A serial study throughout a full cycle in 3 women showed an inverse relationship between plasma uric and synthetic oestrogens produced a fall in plasma uric acid concentration through a uricosuric effect in most subjects of both sexes. Testosterone propionate caused a definite increase in plasma uric acid levels in post-menopausal women while endogenous testosterone changes due to Leydig cell stimulation produced no definite effect in male subjects. Administration of a progesterone preparation produced an effect similar to that of oestrogens in post-menopausal women. The evidence presented here supports ithe view that sex steroids play a significant part in uric acid regulation in biological fluids of both sexes.
对65名健康志愿者（包括正常月经周期的女性、绝经后女性、原发性闭经的女孩和成年男性受试者）进行了研究，以探讨内源性和外源性给予雌激素、雄激素和孕酮对血浆和尿液尿酸及尿酸清除率的影响。对3名女性进行的一个完整周期的系列研究表明，血浆尿酸与合成雌激素之间呈负相关，在大多数男女受试者中，合成雌激素通过促尿酸尿作用使血浆尿酸浓度下降。丙酸睾酮使绝经后女性的血浆尿酸水平明显升高，而由于睾丸间质细胞受刺激导致的内源性睾酮变化在男性受试者中未产生明确影响。给予孕酮制剂对绝经后女性产生的作用与雌激素类似。此处提供的证据支持这样一种观点，即性类固醇在两性生物体液的尿酸调节中起重要作用。
