Severson A R
Br J Exp Pathol. 1969 Feb;50(1):17-21.
Investigation on the presence of mast cells in the remodelling adductor longus-pectineus exostosis, induced by either surgical or BAPN stimulation, and in the healing fracture callus, demonstrated that mast cells were not pathognomonic for the bone lesions of BAPN-treated animals. Numerous mast cells were found in association with the endosteum of the skeletal trabeculae and throughout the new marrow replacing the trabeculae of the experimental lesions, with no increase in the mast cell numbers in the original marrow of the femoral shaft. Mast cells were not present in areas of cartilage resorption, but they were present when resorption and remodelling of the endochondral trabeculae commenced. It is surmised that mast cells play a role in connective tissue resorption and remodelling by supplying a factor necessary for the release of hydrolytic enzymes.
对由手术或BAPN刺激诱导的内收长肌-耻骨外生骨疣重塑以及愈合骨折骨痂中肥大细胞存在情况的研究表明，肥大细胞并非BAPN处理动物骨病变的特征性表现。在骨骼小梁的骨内膜以及整个替代实验性病变小梁的新骨髓中发现了大量肥大细胞，而股骨干原始骨髓中的肥大细胞数量并未增加。肥大细胞不存在于软骨吸收区域，但在软骨内小梁的吸收和重塑开始时出现。据推测，肥大细胞通过提供水解酶释放所需的因子，在结缔组织吸收和重塑中发挥作用。
