荧光素和吲哚菁绿荧光血管造影术在脉络膜萎缩症男性患者及女性携带者研究中的应用。初步报告。

Fluorescein and indocyanine green fluorescence angiography in study of affected males and in female carriers with choroidermia. A preliminary report.

作者信息

Forsius H, Hyvärinen L, Nieminen H, Flower R

出版信息

Acta Ophthalmol (Copenh). 1977 Jun;55(3):459-70. doi: 10.1111/j.1755-3768.1977.tb06123.x.

DOI:10.1111/j.1755-3768.1977.tb06123.x

Abstract

26 males and 13 female carriers of different ages with choroideremia of varying severity were investigated using sodium fluorescein (FAG) and/or indocyanine green (ICG) fluorescence angiography. Females with minor changes present in pigment epithelium amy stay unchanged throughout life or gradually develop into a more advanced stage resembling the fundus picture of severely affected males. In moderately affected females there is a patchy degeneration of pigment epithelium in the macula. Peripapillary degeneration is seen also in indocyanine green fluorescence angiograms. In males, atrophic areas and the remaining choriocapillaris are clearly demonstrated in FAG and less well visible in ICG angiograms. ICG angiograms show choroidal vessels more clearly in cases where the pigment epithelium and the choriocapillaris are still present. In advanced cases in males and females, the choroidal blood circulation is slow.

摘要

对26名男性和13名不同年龄、患有不同严重程度脉络膜视网膜病变的女性携带者，使用荧光素钠（FAG）和/或吲哚菁绿（ICG）荧光血管造影进行了研究。色素上皮有轻微变化的女性，其病情可能终生保持不变，或逐渐发展到更晚期阶段，类似于严重患病男性的眼底图像。中度患病的女性黄斑区色素上皮有斑片状变性。吲哚菁绿荧光血管造影中也可见视乳头周围变性。在男性中，FAG能清晰显示萎缩区域和剩余的脉络膜毛细血管，而ICG血管造影中则不太明显。在色素上皮和脉络膜毛细血管仍然存在的情况下，ICG血管造影能更清晰地显示脉络膜血管。在男性和女性的晚期病例中，脉络膜血液循环缓慢。