Cooper J R, Itokawa Y, Pincus J H
Science. 1969 Apr 4;164(3875):74-5. doi: 10.1126/science.164.3875.74.
Extracts of tissue fluids from a patient with subacute necrotizing encephalomyelopathy inhibit thiamine pyrophosphate-adenosine triphosphate phosphotransferase of rat brain. Brain tissue from the patient, in contrast to normal brain tissue, contained essentially no thiamine triphosphate, although thiamine and its other phosphate esters were present in normal concentrations. These findings suggest a relation between this disease and thiamine triphosphate.
亚急性坏死性脑脊髓病患者的组织液提取物可抑制大鼠脑的硫胺素焦磷酸 - 三磷酸腺苷磷酸转移酶。与正常脑组织相比，该患者的脑组织基本不含三磷酸硫胺素，尽管硫胺素及其其他磷酸酯的浓度正常。这些发现表明这种疾病与三磷酸硫胺素之间存在关联。
