Arnold W, Plester D
Arch Otorhinolaryngol. 1977 Apr 27;215(2):159-78. doi: 10.1007/BF00455863.
Pathologic capillaries are usually seen in the center of an otospongious process. Next to obliteration, dilatation and increased permeability a loss of basement membrane structure is evident. Around the capillaries exists a wide network of mesenchymal cells which have a glycogen like mass within the cytoplasm; glycogen can be delivered into the extracellular fluidspace. Free erythrocytes are located around many vessels. Near the margin of the lacunae decalcificated areas are seen; in the center of these areas osteocytes undergo lysis; they show intracytoplasmatic deposits of apatite which we assume to be located within the mitochondria. The collagen structure in the neighbourhood of the osteocytes seems to be damaged. Once the resorptive process has reached the perilymphatic surface of the footplate there comes to an connection between the otospongiotic lacunae and the vestibule. Free erythrocytes, glycogen like drops and lysosomes are delivered into the perilymph. Comparing the histological results with the operative results in patients with floride otosclerosis we conclude that operation should be done as early as possible to prevent damage from the inner ear, caused by the continuous intoxication of the perilymph from the otosclerotic focus.
病理性毛细血管通常见于耳海绵化过程的中心。除了闭塞、扩张和通透性增加外，基底膜结构的丧失也很明显。毛细血管周围存在广泛的间充质细胞网络，其细胞质内有类似糖原的物质；糖原可被输送到细胞外液间隙。许多血管周围有游离红细胞。在陷窝边缘附近可见脱钙区域；在这些区域的中心，骨细胞发生溶解；它们显示出细胞质内的磷灰石沉积物，我们认为这些沉积物位于线粒体内。骨细胞附近的胶原结构似乎受损。一旦吸收过程到达镫骨足板的外淋巴表面，耳海绵化陷窝与前庭之间就会建立连接。游离红细胞、类似糖原的液滴和溶酶体被输送到外淋巴中。将组织学结果与重度耳硬化症患者的手术结果进行比较，我们得出结论，应尽早进行手术，以防止内耳因耳硬化病灶对外淋巴的持续毒害而受损。
