[Pharmacological effect of piprozoline on the exocrine pancreas of dogs (author's transl)].

Ethyl (Z)-(3-ethyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)-acetate (piprozoline, Gö 919, Probilin) and its main metabolite Gö 3284 cause a long-acting stimulation of the ecbolic function of the exocrine pancreas in the dog after intraduodenal administration or after i.v. injection. This has been demonstrated by canulation of the ductus pancreaticus accessorius and by perfusion of the small bowel as well as by photometric evaluation of the perfusion streams and determinations of the activities of alpha-amylase, lipase and trypsin in the 2-min fractions thereafter. Piprozoline does not cause a rise of the bicarbonate secretion and volume. In its action to the exocrine pancreas it resembles very much cholecystokinin-pancreozymin. The value of piprozoline is discussed with regard to its stimulating effect on the ontogenetic unit of the epigastric region.