von Kleist D, Zschiedrich M, Stopik D, Hampel K E
Dtsch Z Verdau Stoffwechselkr. 1981;41(5):219-24.
The action of somatostatin (250 microgram i. v. + 125 microgram/30 min i. v.) on pancreatic secretion was studied in 8 volunteers and on biliary secretion as measured through a T-tube in 7 volunteers during background stimulation of secretin and pancreozymin (1 U/kg/h). Additional injection of somatostatin was accompanied by a significant (p less than 0,05) decrease in volume and in bicarbonate output for a short time and a significant (p less than 0,05) decrease in trypsin, amylase and lipase output for the studied period. There was no decrease in volume output and bicarbonate concentration as measured in the T-tube. The effect of somatostatin in abolishing the pancreozymin induced contraction of the gallbladder was documented by sonography. The temporary reduction of volume and bicarbonate output in the duodenal lumen could be considered as an inhibitory effect of somatostatin on gallbladder contraction and not as an effect on the exocrine pancreas.
在8名志愿者中研究了生长抑素（静脉注射250微克+静脉注射125微克/30分钟）对胰腺分泌的作用，并在7名志愿者中通过T管测量了在促胰液素和胰酶泌素（1单位/千克/小时）背景刺激下对胆汁分泌的作用。额外注射生长抑素后，短期内胰液量和碳酸氢盐分泌量显著（p<0.05）减少，在研究期间胰蛋白酶、淀粉酶和脂肪酶分泌量显著（p<0.05）减少。T管测量的胆汁量和碳酸氢盐浓度没有下降。超声检查记录了生长抑素消除胰酶泌素诱导的胆囊收缩的作用。十二指肠腔内胰液量和碳酸氢盐分泌量的暂时减少可被认为是生长抑素对胆囊收缩的抑制作用，而不是对外分泌胰腺的作用。
