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[十二指肠注入淀粉酶后胰腺酶分泌抑制的选择性]

[Selectivity of inhibition of enzyme secretion by the pancreas after introduction of amylase into the duodenum].

作者信息

Korot'ko G F, Baĭbekova G D

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1986 Jul;72(7):972-81.

PMID:2428675
Abstract

Intraduodenal administration of both pancreatic and vegetative amylase induces inhibition of pancreatic secretion of the amylase. The secretion activated with intraduodenal administration of oxidized hydrolysine or i.v. administration of secretin, is also inhibited. High doses of intraduodenal amylase inhibit secretion of the juice's other components too. I.v. amylase inhibit secretion of bicarbonates and hydrolases in the pancreas. The selective inhibiting effect of amylase is sharply reduced with starch solution. The duodenum seems to be able to inhibit selectively the pancreatic enzymes secretion, this mechanism participating in urgent adaptations of the pancreatic juice enzyme range to properties of duodenal chyme.

摘要

十二指肠内注射胰腺淀粉酶和植物淀粉酶均可抑制胰腺淀粉酶的分泌。十二指肠内注射氧化水解赖氨酸或静脉注射促胰液素激活的分泌也受到抑制。高剂量的十二指肠内淀粉酶也会抑制胰液其他成分的分泌。静脉注射淀粉酶会抑制胰腺中碳酸氢盐和水解酶的分泌。淀粉溶液会使淀粉酶的选择性抑制作用大幅降低。十二指肠似乎能够选择性地抑制胰腺酶的分泌,这种机制参与了胰液酶谱对十二指肠食糜特性的紧急适应性调节。

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