对来自东非三个地区的布氏锥虫分离株抗原关系的研究。
A study of the antigenic relationships of isolates of Trypanosoma brucei from three areas in East Africa.
作者信息
Paris J, Wilson A J, Gray A R
出版信息
Ann Trop Med Parasitol. 1976 Mar;70(1):45-51. doi: 10.1080/00034983.1976.11687093.
Eleven stabilates of T. brucei, prepared from isolates collected from cattle and tsetse flies in three areas of East Africa, were compared serologically by direct agglutination tests, using (a) stabilate-specific antisera prepared in rats and (b)antisera to the predominant variant antigens of each isolate prepared in rabbits. The results indicated that groups of isolates from any one area tended to produce antigens in common, whereas isolates from different areas were generally antigenically distinct. The comparison of isolates of T. brucei on the basis of their predominant variant antigens, as a technique, was more simple to effect, and more sensitive in the detection of antigenic relationships, than comparison founded on basic strain antigens.
从东非三个地区的牛和采采蝇中分离出的布氏锥虫制备了11种稳定株，通过直接凝集试验进行血清学比较，使用（a）在大鼠中制备的稳定株特异性抗血清和（b）在兔子中制备的针对每种分离株主要变异抗原的抗血清。结果表明，来自任何一个地区的分离株群体往往产生共同的抗原，而来自不同地区的分离株通常在抗原性上是不同的。作为一种技术，基于主要变异抗原对布氏锥虫分离株进行比较，比基于基础菌株抗原的比较更易于实施，并且在检测抗原关系方面更敏感。
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