与甲状腺素状态相关的泛醌代谢
Metabolism of ubiquinone in relation to thyroxine status.
作者信息
Inamdar A R, Ramasarma T
出版信息
Biochem J. 1969 Feb;111(4):479-86. doi: 10.1042/bj1110479.
Abstract
- Under conditions of thyrotoxicosis induced by feeding rats with iodinated casein, ubiquinone concentration was found to increase in the liver by increased synthesis and by partly decreased catabolism leading to its accumulation. The increased ubiquinone was found primarily in the mitochondrial and supernatant fractions. 2. Supplementing the diet with thyroxine, at less than toxic doses, also increased the synthesis and the concentration of ubiquinone in the liver. 3. In the condition of hypothyroidism obtained by feeding rats with thiouracil the concentration and the synthesis of ubiquinone in the liver showed a small decrease. 4. Synthesis of ubiquinone in liver slices was partially inhibited by addition of thyroxine in vitro. Therefore the activation effect on ubiquinone synthesis of excess of thyroxine in the intact animals appears to be by an indirect mechanism.
摘要
- 在给大鼠喂食碘化酪蛋白诱导甲状腺毒症的条件下，发现肝脏中泛醌浓度因合成增加和部分分解代谢减少导致其积累而升高。增加的泛醌主要存在于线粒体和上清液部分。2. 用低于中毒剂量的甲状腺素补充饮食，也会增加肝脏中泛醌的合成和浓度。3. 在给大鼠喂食硫脲获得甲状腺功能减退的情况下，肝脏中泛醌的浓度和合成略有下降。4. 在体外添加甲状腺素会部分抑制肝切片中泛醌的合成。因此，完整动物体内过量甲状腺素对泛醌合成的激活作用似乎是通过间接机制实现的。
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