通过给予二甲基亚硝胺使完整动物体内的脱氧核糖核酸甲基化的稳定性。不同剂量下体内和体外的分解速率。
Stability of deoxyribonucleic acid methylated in the intact animal by administration of dimethylnitrosamine. Rate of breakdown in vivo and in vitro at different dosages.
作者信息
Craddock V M
出版信息
Biochem J. 1969 Feb;111(4):497-502. doi: 10.1042/bj1110497.
Abstract
- The effect of administration of various dosages of dimethylnitrosamine on the extent of methylation of liver and kidney nucleic acids in the intact rat was studied. Methylation of liver nucleic acids was linearly related to the dosage, but decreasing the dose produced relatively less lowering of the extent of alkylation of kidney nucleic acids. 2. The rates of disappearance of 7-methylguanine from DNA during the 2 days after administration of dimethylnitrosamine in the intact animal and on incubation under simulated physiological conditions in vitro were compared. At a high dosage this rate was greater in vivo than in vitro. At a low dosage the small difference between the two rates was not thought to be sufficient evidence for existence of a specific enzymic excision of the abnormal base.
摘要
- 研究了给完整大鼠施用不同剂量二甲基亚硝胺对肝脏和肾脏核酸甲基化程度的影响。肝脏核酸的甲基化与剂量呈线性关系，但降低剂量时，肾脏核酸烷基化程度的降低相对较少。2. 比较了在完整动物中施用二甲基亚硝胺后2天内以及在体外模拟生理条件下孵育时，DNA中7-甲基鸟嘌呤的消失速率。高剂量时，体内的消失速率大于体外。低剂量时，两种速率之间的微小差异被认为不足以作为存在异常碱基特异性酶切的充分证据。
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本文引用的文献
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Induction of kidney tumours in the rat with dimethylnitrosamine (N-nitrosodimethylamine).用二甲基亚硝胺（N-亚硝基二甲胺）诱导大鼠肾肿瘤。
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