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Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nerbous system by ethyinitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues.

作者信息

Goth R, Rajewsky M F

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;82(1):37-64. doi: 10.1007/BF00304382.

DOI:10.1007/BF00304382
PMID:4280214
Abstract
摘要

相似文献

1
Molecular and cellular mechanisms associated with pulse-carcinogenesis in the rat nerbous system by ethyinitrosourea: ethylation of nucleic acids and elimination rates of ethylated bases from the DNA of different tissues.乙基亚硝基脲诱导大鼠神经系统脉冲致癌作用的分子和细胞机制：核酸的乙基化及不同组织DNA中乙基化碱基的消除速率
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;82(1):37-64. doi: 10.1007/BF00304382.
2
[Ethylation of guanine-N-7 in the nucleic acids of rat embryos and liver by ethylnitrosourea].
Z Naturforsch B. 1971 Oct;26(10):1076-7. doi: 10.1515/znb-1971-1032.
3
Nitrosamine-induced carcinogenesis. The alkylation of N-7 of guanine of nucleic acids of the rat by diethylnitrosamine, N-ethyl-N-nitrosourea and ethyl methanesulphonate.亚硝胺诱导的致癌作用。二乙基亚硝胺、N-乙基-N-亚硝基脲和甲磺酸乙酯对大鼠核酸鸟嘌呤N-7位的烷基化作用。
Biochem J. 1971 Dec;125(3):841-7. doi: 10.1042/bj1250841.
4
Ethylation of nucleic acids by ethylnitrosourea-1- 14 C in the fetal and adult rat.14C标记的乙基亚硝基脲对胎鼠和成鼠核酸的乙基化作用
Cancer Res. 1972 Jul;32(7):1501-5.
5
Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea.大鼠脑DNA中O6-乙基鸟嘌呤的持久性：与乙基亚硝基脲诱导的神经系统特异性致癌作用的相关性。
Proc Natl Acad Sci U S A. 1974 Mar;71(3):639-43. doi: 10.1073/pnas.71.3.639.
6
Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea.单次经胎盘给予N-甲基-N-亚硝基脲后，各种大鼠胎儿和母体组织DNA中甲基化嘌呤的持续性及子代中的致癌作用。
Int J Cancer. 1983 Jun 15;31(6):779-84. doi: 10.1002/ijc.2910310618.
7
Alkylation of rat brain nucleic acids by N-methyl-N-nitrosourea and methyl methanesulphonate.N-甲基-N-亚硝基脲和甲磺酸甲酯对大鼠脑核酸的烷基化作用。
J Neurochem. 1973 Feb;20(2):595-606. doi: 10.1111/j.1471-4159.1973.tb12158.x.
8
Retention of promutagenic O6-ethylguanine in the DNA of various rat tissues following transplacental inoculation with ethylnitrosourea.
Cancer Lett. 1980 May;9(3):199-205. doi: 10.1016/0304-3835(80)90087-7.
9
Rapid loss of 7-methylguanine from liver nucleic acids in mice during the initial stage of liver carcinogenesis induced by dimethylnitrosamine.在二甲基亚硝胺诱导的小鼠肝癌发生初始阶段，肝脏核酸中7-甲基鸟嘌呤迅速丢失。
Biochem Biophys Res Commun. 1974 May 7;58(1):242-9. doi: 10.1016/0006-291x(74)90918-8.
10
Reaction of methyl methanesulphonate with nucleic acids of fetal and newborn rats in vivo.甲磺酸甲酯与新生大鼠和胎鼠核酸在体内的反应。
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;81(3-4):273-83. doi: 10.1007/BF00305030.

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1
The inhibiting activity of meadowsweet extract on neurocarcinogenesis induced transplacentally in rats by ethylnitrosourea.绣线菊提取物对大鼠经胎盘由乙基亚硝基脲诱导的神经致癌作用的抑制活性。
J Neurooncol. 2017 Feb;131(3):459-467. doi: 10.1007/s11060-016-2323-6. Epub 2016 Nov 12.
2
Inheritance of susceptibility to induction of nephroblastomas in the Noble rat.诺布尔大鼠中肾母细胞瘤诱导易感性的遗传
Differentiation. 2009 Apr;77(4):424-32. doi: 10.1016/j.diff.2008.12.003. Epub 2009 Jan 29.
3
Effects of inhibition of O6-alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea.

本文引用的文献

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The reaction of mono- and di-functional alkylating agents with nucleic acids.单官能和双官能烷基化剂与核酸的反应。
Biochem J. 1961 Sep;80(3):496-503. doi: 10.1042/bj0800496.
2
REGENERATION OF MAMMALIAN LIVER.哺乳动物肝脏的再生
Int Rev Cytol. 1963;15:245-300. doi: 10.1016/s0074-7696(08)61119-5.
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REACTION OF SOME MUTAGENIC AND CARCINOGENIC COMPOUNDS WITH NUCLEIC ACIDS.
J Cell Comp Physiol. 1964 Oct;64:SUPPL 1:111-27.
抑制大鼠O6-烷基鸟嘌呤-DNA烷基转移酶对甲基亚硝基脲和乙基亚硝基脲致癌作用的影响。
Jpn J Cancer Res. 1994 Mar;85(3):226-30. doi: 10.1111/j.1349-7006.1994.tb02086.x.
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The cytotoxic effect of ethylnitrosourea on the developing rat cerebellum. Morphologic observations.乙基亚硝基脲对发育中大鼠小脑的细胞毒性作用。形态学观察。
Acta Neuropathol. 1981;55(4):257-61. doi: 10.1007/BF00690987.
5
A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA.小鼠肝脏中用于修复甲基化DNA中O6-甲基鸟嘌呤损伤的系统。
Nucleic Acids Res. 1981 Jul 10;9(13):3089-103. doi: 10.1093/nar/9.13.3089.
6
Antibodies specific for DNA components structurally modified by chemical carcinogens.针对经化学致癌物结构修饰的DNA成分的特异性抗体。
J Cancer Res Clin Oncol. 1981;102(2):99-113. doi: 10.1007/BF00410662.
7
Human lymphoblasts contain DNA glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not O6-alkylguanines or 1-alkyladenines.人类淋巴母细胞含有DNA糖基化酶活性，可切除N-3和N-7甲基及乙基嘌呤，但不能切除O6-烷基鸟嘌呤或1-烷基腺嘌呤。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):856-60. doi: 10.1073/pnas.78.2.856.
8
The problem of thresholds in chemical carcinogenesis some views on theoretical and practical aspects.化学致癌作用中的阈值问题——关于理论与实践方面的一些观点
J Cancer Res Clin Oncol. 1980;97(1):1-14. doi: 10.1007/BF00411273.
9
O6-methylguanine repair in liver cells in vivo: comparison between G1- and S-phase of the cell cycle.体内肝细胞中的O6-甲基鸟嘌呤修复：细胞周期G1期和S期之间的比较
J Cancer Res Clin Oncol. 1984;108(1):36-45. doi: 10.1007/BF00390971.
10
Development and growth of early preneoplastic lesions induced in the liver by chemical carcinogens.化学致癌物诱导的肝脏早期癌前病变的发展与生长
J Cancer Res Clin Oncol. 1983;106(2):85-92. doi: 10.1007/BF00395384.
4
FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES.核酸及其组成核苷酸烷基化的进一步研究
Biochem J. 1963 Oct;89(1):127-38. doi: 10.1042/bj0890127.
5
[Cell proliferation in normal and malignant tissues: H3-thymidine incorporation in vitro under standard conditions].[正常与恶性组织中的细胞增殖：标准条件下体外 H3-胸腺嘧啶核苷掺入]
Biophysik. 1966;3(1):65-93. doi: 10.1007/BF01191058.
6
Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides.脱氧鸟苷的O-6烷基化与亚硝胺和亚硝酰胺的致突变性和致癌性之间可能存在的关联。
Nature. 1969 Jul 12;223(5202):206-7. doi: 10.1038/223206a0.
7
Stability of deoxyribonucleic acid methylated in the intact animal by administration of dimethylnitrosamine. Rate of breakdown in vivo and in vitro at different dosages.通过给予二甲基亚硝胺使完整动物体内的脱氧核糖核酸甲基化的稳定性。不同剂量下体内和体外的分解速率。
Biochem J. 1969 Feb;111(4):497-502. doi: 10.1042/bj1110497.
8
Nitrosamine-induced carcinogenesis. The alklylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate.亚硝胺诱导的致癌作用。N-甲基-N-亚硝基脲、二甲基亚硝胺、硫酸二甲酯和甲磺酸甲酯对大鼠核酸的烷基化作用。
Biochem J. 1968 Nov;110(1):39-47. doi: 10.1042/bj1100039.
9
Repair of alkylated DNA in mammalian cells.哺乳动物细胞中烷基化DNA的修复
Nature. 1968 Jun 8;218(5145):970-2. doi: 10.1038/218970a0.
10
Tissue-dependent differences in DNA methylation products of mice treated with methyl-labelled methylnitrosourea.用甲基标记的甲基亚硝基脲处理的小鼠DNA甲基化产物的组织依赖性差异。
Int J Cancer. 1971 May 15;7(3):436-42. doi: 10.1002/ijc.2910070309.