苯丁酸氮芥对吉田腹水肉瘤药物敏感株和耐药株谷胱甘肽代谢酶的一些影响。
Some effects of chlorambucil on enzymes of glutathione metabolism in drug-sensitive and -resistant strains of the Yoshida ascites sarcoma.
作者信息
Harrap K R, Jackson R C, Hill B T
出版信息
Biochem J. 1969 Feb;111(4):603-6. doi: 10.1042/bj1110603.
Abstract
- Yoshida ascites cells from a strain sensitive to chemotherapy with alkylating agents contained elevated activities of the two enzymes directly responsible for glutathione synthesis, in comparison with a resistant cell strain. The activities of the glutathione-degrading enzyme gamma-glutamyltranspeptidase were comparable in both cell strains. 2. After parenteral administration of chlorambucil to rats carrying either strain of tumour, the activities of the glutathione-synthetic enzymes increased in the sensitive cells, but remained unchanged in the resistant cells. Drug treatment was without effect on the gamma-glutamyltranspeptidase activity of either cell strain. 3. The activities of a number of enzymes concerned in the oxidoreduction of glutathione remained unchanged after the administration of chlorambucil to rats carrying either strain of cells.
摘要
- 与耐药细胞株相比，对烷化剂化疗敏感的吉田腹水细胞株中，直接负责谷胱甘肽合成的两种酶的活性升高。两种细胞株中谷胱甘肽降解酶γ-谷氨酰转肽酶的活性相当。2. 给携带任一肿瘤细胞株的大鼠经肠胃外给予苯丁酸氮芥后，敏感细胞中谷胱甘肽合成酶的活性增加，而耐药细胞中的活性保持不变。药物处理对任一细胞株的γ-谷氨酰转肽酶活性均无影响。3. 给携带任一细胞株的大鼠给予苯丁酸氮芥后，一些参与谷胱甘肽氧化还原的酶的活性保持不变。
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THE ROLE OF DPNASE IN THE MECHANISM OF ACTION OF AN ANTITUMOR ALKYLATING AGENT ON EHRLICH ASCITES CELLS.脱氧核糖核酸酶在一种抗肿瘤烷化剂对艾氏腹水癌细胞作用机制中的作用
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