Donaldson G W, Davies S H, Darg A, Richmond J
J Clin Pathol. 1969 Mar;22(2):199-204. doi: 10.1136/jcp.22.2.199.
Coagulation studies were carried out on 30 patients with chronic liver disease. The clotting defect was complex and involved factors V, VII, IX (Christmas factor), and prothrombin. Some patients showed a significant depression of factor IX in the presence of a normal one-stage prothrombin time. Thrombotest was found to be a good indicator of factor IX deficiency in this group of patients and may be of use as an additional liver function test. The screening of patients with liver disease for surgery or liver biopsy should assess the coagulation factors involved in both intrinsic and extrinsic thromboplastin generation.
对30例慢性肝病患者进行了凝血研究。凝血缺陷很复杂，涉及因子V、VII、IX（克里斯马斯因子）和凝血酶原。一些患者在一期凝血酶原时间正常的情况下，因子IX显著降低。发现凝血试验是该组患者因子IX缺乏的良好指标，可用作一项额外的肝功能检查。对拟行手术或肝活检的肝病患者进行筛查时，应评估内源性和外源性凝血活酶生成所涉及的凝血因子。
