Gabbe S G, Lowensohn R I, Mestman J H, Freeman R K, Goebelsmann U
Am J Obstet Gynecol. 1977 Aug 1;128(7):757-60. doi: 10.1016/0002-9378(77)90716-5.
The amniotic fluid lecithin/sphingomyelin (L/S) ratio was determined in 182 pregnancies complicated by Classes B and C diabetes and in 28 patients with Classes D, F, and R diabetes. These data were retrospectively correlated with the occurrence of the respiratory distress syndrome (RDS) or hyaline membrane disease (HMD). Only four cases of RDS and two cases of HMD were observed in 200 patients with an L/S ratio of 2.0 or greater prior to delivery. This 3 per cent incidence of complications is no higher than that of the nondiabetic population in our institution. Seven of 10 neonates with an antenatal L/S ratio of 1.5 to 1.9 developed RDS. An L/S ratio of 2.0 or more appears to be reliable predictor of fetal pulmonary maturity even in pregnancies complicated by diabetes mellitus.
对182例合并B级和C级糖尿病的孕妇以及28例合并D级、F级和R级糖尿病的患者测定了羊水卵磷脂/鞘磷脂（L/S）比值。这些数据与呼吸窘迫综合征（RDS）或透明膜病（HMD）的发生情况进行了回顾性关联分析。在分娩前L/S比值为2.0或更高的200例患者中，仅观察到4例RDS和2例HMD。这种3%的并发症发生率并不高于我们机构中非糖尿病人群的发生率。产前L/S比值为1.5至1.9的10例新生儿中有7例发生了RDS。即使在合并糖尿病的妊娠中，L/S比值为2.0或更高似乎也是胎儿肺成熟度的可靠预测指标。
