博来霉素与戊霉素联合使用对EMT6小鼠肿瘤细胞在体外和体内存活的影响。

The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo.

作者信息

Twentyman P R

出版信息

Br J Cancer. 1976 Apr;33(4):459-64. doi: 10.1038/bjc.1976.71.

DOI:10.1038/bjc.1976.71

PMID:57791

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2025089/

Abstract

The combined effect of bleomycin and the polyene antibiotic, pentamycin, upon the survival of EMT6 tumour cells has been studied both in vitro and in vivo. During growth of the cells as a monolayer in vitro, a very marked potentiation of bleomycin action is seen during the exponential and early plateau phases of growth, but little potentiation occurs in late plateau phase. The effect of exposing the cells to the two drugs consecutively in either order is greater than if the two agents are used at the same time. In vivo, it does not appear that pentamycin can greatly increase the cytocidal effect of bleomycin.

摘要

已经在体外和体内研究了博来霉素和多烯抗生素戊霉素对EMT6肿瘤细胞存活的联合作用。在细胞作为单层在体外生长期间，在生长的指数期和早期平台期可以看到博来霉素作用的非常显著的增强，但在晚期平台期几乎没有增强。以任何顺序将细胞连续暴露于两种药物的效果大于同时使用这两种药物的效果。在体内，戊霉素似乎不能大大增加博来霉素的杀细胞作用。

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本文引用的文献

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Synergistic effect of amphotericin B and 1,3-bis(2-chloroethyl)-1-nitrosourea against a transplantable AKR leukemia.两性霉素B与1,3-双（2-氯乙基）-1-亚硝基脲对可移植性AKR白血病的协同作用

Cancer Res. 1974 May;34(5):974-8.

2

The sensitivity to bleomycin of a solid mouse tumour at different stages of growth.实体小鼠肿瘤在不同生长阶段对博来霉素的敏感性。

Br J Cancer. 1974 Nov;30(5):469-72. doi: 10.1038/bjc.1974.222.

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Potentiation of bleomycin by an antifungal polyene, pentamycin, in transformed animal cells.

Cancer Res. 1974 Dec;34(12):3258-61.

4

Radioautographic studies on the intracellular distribution of bleomycin-14C in mouse tumor cells.关于博来霉素 - 14C在小鼠肿瘤细胞内分布的放射自显影研究。

Cancer Res. 1974 Nov;34(11):2969-74.

5

Potentiation of 5-fluorouracil, chromomycin A3, and bleomycin by amphotericin B or polymyxin B in transformed fibroblastic cells.两性霉素B或多粘菌素B对转化成纤维细胞中5-氟尿嘧啶、放线菌素A3和博来霉素的增效作用。

Antimicrob Agents Chemother. 1973 May;3(5):580-4. doi: 10.1128/AAC.3.5.580.

6

Effect of bleomycin on mammalian cell survival.

J Natl Cancer Inst. 1972 Oct;49(4):1093-100.

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