博来霉素与戊霉素联合使用对EMT6小鼠肿瘤细胞在体外和体内存活的影响。
The effect of bleomycin and pentamycin in combination on the survival of EMT6 mouse tumour cells in vitro and in vivo.
作者信息
Twentyman P R
出版信息
Br J Cancer. 1976 Apr;33(4):459-64. doi: 10.1038/bjc.1976.71.
The combined effect of bleomycin and the polyene antibiotic, pentamycin, upon the survival of EMT6 tumour cells has been studied both in vitro and in vivo. During growth of the cells as a monolayer in vitro, a very marked potentiation of bleomycin action is seen during the exponential and early plateau phases of growth, but little potentiation occurs in late plateau phase. The effect of exposing the cells to the two drugs consecutively in either order is greater than if the two agents are used at the same time. In vivo, it does not appear that pentamycin can greatly increase the cytocidal effect of bleomycin.
已经在体外和体内研究了博来霉素和多烯抗生素戊霉素对EMT6肿瘤细胞存活的联合作用。在细胞作为单层在体外生长期间，在生长的指数期和早期平台期可以看到博来霉素作用的非常显著的增强，但在晚期平台期几乎没有增强。以任何顺序将细胞连续暴露于两种药物的效果大于同时使用这两种药物的效果。在体内，戊霉素似乎不能大大增加博来霉素的杀细胞作用。
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