两性霉素B或多粘菌素B对转化成纤维细胞中5-氟尿嘧啶、放线菌素A3和博来霉素的增效作用。
Potentiation of 5-fluorouracil, chromomycin A3, and bleomycin by amphotericin B or polymyxin B in transformed fibroblastic cells.
作者信息
Kuwano M, Kamiya T, Endo H, Komiyama S
出版信息
Antimicrob Agents Chemother. 1973 May;3(5):580-4. doi: 10.1128/AAC.3.5.580.
Abstract
By using cultured, transformed fibroblastic cells, antitumor agents including cytosine arabinoside, thio-tepa, nitrogen mustard N-oxide, mitomycin C, chromomycin A3, 5-fluorouracil, daunomycin, vinblastine, vincristine, and bleomycin A2 were screened for the potentiation of their activity by amphotericin B or polymyxin B. Among them, the action of 5-fluorouracil and chromomycin A3 on ribonucleic acid synthesis was potentiated in their action by amphotericin B, not by polymyxin B. Bleomycin A2 was potentiated in its action on deoxyribonucleic acid and ribonucleic acid synthesis only by polymyxin B.
摘要
通过使用培养的转化成纤维细胞，筛选了包括阿糖胞苷、噻替派、氮芥N -氧化物、丝裂霉素C、色霉素A3、5 -氟尿嘧啶、柔红霉素、长春碱、长春新碱和博来霉素A2在内的抗肿瘤药物，以研究两性霉素B或多粘菌素B对其活性的增强作用。其中，两性霉素B可增强5 -氟尿嘧啶和色霉素A3对核糖核酸合成的作用，而多粘菌素B则不能。博来霉素A2仅在对脱氧核糖核酸和核糖核酸合成的作用上被多粘菌素B增强。
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本文引用的文献
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Biological studies on bleomycin A.博来霉素A的生物学研究。
J Antibiot (Tokyo). 1967 Jul;20(3):149-55.
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New antibiotics, bleomycin A and B.新型抗生素，博来霉素A和B。
J Antibiot (Tokyo). 1966 Sep;19(5):200-9.
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Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin.吐温80对耐放线菌素D和柔红霉素的中国仓鼠细胞药物效应的增强作用。
Cancer Res. 1972 Jun;32(6):1195-200.
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On the mechanism of action of bleomycin: scission of DNA strands in vitro and in vivo.关于博来霉素的作用机制：体外和体内DNA链的断裂
J Antibiot (Tokyo). 1969 Sep;22(9):446-8. doi: 10.7164/antibiotics.22.446.
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Potentiation of fusidic acid and lentinan effects upon normal and transformed fibroblastic cells by amphotericin B.两性霉素B增强夫西地酸和香菇多糖对正常和成纤维细胞转化细胞的作用。
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7
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Fluorinated pyrimidines.
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