动脉壁的纤溶酶原激活剂。

The plasminogen activator of the arterial wall.

作者信息

Donner L, Klener P, Roth Z

出版信息

Thromb Haemost. 1977 Jun 30;37(3):436-43.

Abstract

The plasminogen activator in 645 specimens of various human arteries--thoracic, abdominal aorta, carotic, pulmonary, renal, basilar, coronary - was studied using Todd's histochemical method. 92 cadavers were used, 1--18 hours post mortem from subjects aged from 272 days to 83 years. 45 specimens of pulmonary, renal and splenic arteries were obtained during surgery. The greatest fibrinolytic activity was within the adventitia. Intima occasionally showed very little fibrinolytic activity, or none at all. No statistically significant differences in plasminogen activator activity were found between the various arteries examined. A statistically significant increase in fibrinolysis in adventitia of atherosclerotic arteries was established. No correlation was found between the fibrinolytic activity of the arteries and their alkaline phosphatase content. Some properties of the plasminogen activator of the arterial vessel wall were evaluated. Influence of storage, inactivation with epsilonaminocaproic acid and extracted with potassium thiocyanate was studied.

摘要

采用托德组织化学方法，对645份来自人体不同动脉（胸主动脉、腹主动脉、颈动脉、肺动脉、肾动脉、基底动脉、冠状动脉）的标本进行纤溶酶原激活物研究。使用了92具尸体，受试者年龄从272天至83岁，死亡时间为死后1至18小时。45份肺、肾和脾动脉标本取自手术过程。最大的纤溶活性位于外膜。内膜偶尔显示出极少的纤溶活性，或根本没有。在所检查的不同动脉之间，未发现纤溶酶原激活物活性有统计学显著差异。已证实动脉粥样硬化动脉外膜中的纤溶有统计学显著增加。未发现动脉的纤溶活性与其碱性磷酸酶含量之间存在相关性。对动脉血管壁纤溶酶原激活物的一些特性进行了评估。研究了储存的影响、用ε-氨基己酸灭活以及用硫氰酸钾提取的情况。