Möller E
Immunology. 1969 May;16(5):609-19.
Mouse peritoneal exudate cells, and to a lesser degree spleen cells, can cause haemolysis of both syngeneic and allogeneic mouse red blood cells whereas lymph node and tumour cells are ineffective. The reaction was clearly detectable after 0.5–1 hour, and is usually complete after 5–6 hours at 37°. An analogous reaction was found also with sheep red blood cell targets, but haemolysis was weaker and a significant effect was not obtained until 24 hours later. The degree of haemolysis did not increase after the addition of complement. Hemolysis was not potentiated when specifically sensitized cells were employed or when PHA was present. Viability and active metabolism of the PE cell was essential for haemolysis. Only red blood cells were affected by the PE cells, nucleated target tumour cells being resistant. It was concluded that macrophages were responsible for haemolysis, which was not mediated by antibody and complement, but represented an active macrophage reaction unrelated to previously known mechanisms of haemolysis .
小鼠腹腔渗出细胞，以及程度较轻的脾细胞，能够引起同基因和异基因小鼠红细胞的溶血，而淋巴结和肿瘤细胞则无此作用。该反应在0.5 - 1小时后即可明显检测到，在37℃下5 - 6小时后通常完成。用绵羊红细胞作为靶细胞也发现了类似反应，但溶血作用较弱，直到24小时后才获得显著效果。添加补体后溶血程度并未增加。当使用特异性致敏细胞或存在PHA时，溶血作用并未增强。PE细胞的活力和活跃代谢对于溶血至关重要。只有红细胞受到PE细胞的影响，有核的靶肿瘤细胞具有抗性。得出的结论是，巨噬细胞是溶血的原因，其并非由抗体和补体介导，而是代表一种与先前已知溶血机制无关的活跃巨噬细胞反应。
