补骨脂素对器官培养的大鼠松果体褪黑素形成的影响。
Influence of psoralen on melatonin formation in rat pineal gland in organ culture.
作者信息
Bäckström M, Wetterberg L
出版信息
Acta Endocrinol (Copenh). 1977 Nov;86(3):659-66. doi: 10.1530/acta.0.0860659.
8-Methoxypsoralen (10(-4) M) added to the medium of rat pineal glands in organ culture induces a five-fold increase of 14C-labelled N-acetylserotonin and melatonin formation when serotonin is used as 14C-labelled precursor. Addition of d-amphetamine (10(-5) M) to pineal glands also results in an increase of N-acetylserotonin and melatonin formation. This increase is enhanced by the addition of 8-methoxypsoralen (10(-5) M). In pineal glands pre-incubated for 24 h 8-methoxypsoralen (10(-4) M) caused an increased production of N-acetylserotonin and melatonin. This indicates that the effect of 8-methoxypsoralen is mediated through a postsynaptic event and not by release of noradrenaline or blocked re-uptake of amines to nerve terminals in the pineal gland. Further studies of the clinical significance of the effect of psoralen on pineal gland metabolism seems warranted.
在器官培养中，向大鼠松果体培养基中添加8-甲氧基补骨脂素（10⁻⁴ M），当使用血清素作为¹⁴C标记的前体时，可使¹⁴C标记的N-乙酰血清素和褪黑素的生成增加五倍。向松果体中添加d-苯丙胺（10⁻⁵ M）也会导致N-乙酰血清素和褪黑素生成增加。添加8-甲氧基补骨脂素（10⁻⁵ M）可增强这种增加。在预孵育24小时的松果体中，8-甲氧基补骨脂素（10⁻⁴ M）导致N-乙酰血清素和褪黑素的产量增加。这表明8-甲氧基补骨脂素的作用是通过突触后事件介导的，而不是通过去甲肾上腺素的释放或胺类向松果体神经末梢的再摄取受阻。补骨脂素对松果体代谢作用的临床意义似乎值得进一步研究。
Zotero 插件