多态性与药物代谢缺陷作为毒性反应的触发因素（作者译）
[Polymorphisms and deficient drug metabolism as triggers of toxic reactions (author's transl)].
作者信息
Dengler H J, Eichelbaum M
出版信息
Arzneimittelforschung. 1977;27(96):1836-44.
PMID:579150
Abstract
The influences of polymorphisms and pharmacokinetic defects of drug metabolism as causes of toxic drug reactions are presented. The different mechanisms of toxic side effects mediated by alterations of the metabolism and excretion of drugs are discussed.
摘要
本文介绍了药物代谢的多态性和药代动力学缺陷作为药物毒性反应原因的影响。讨论了由药物代谢和排泄改变介导的毒性副作用的不同机制。
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