Eichelbaum M, Woolhouse N M
Eur J Clin Pharmacol. 1985;28(1):79-83. doi: 10.1007/BF00635712.
Sparteine oxidation, which exhibits genetic polymorphism in various Caucasian populations, was studied in 154 unrelated Ghanaian subjects. Mean total urinary recovery of sparteine and 2- and 5-dehydrosparteines (56.6 +/- 16.6% of the dose) was not different from Caucasians. In contrast to Caucasians, amongst whom 6.3 to 9% of the population are poor metabolizers (PM), no PM subject was observed in the Ghanaian population sample. The data appear to indicate allelic differences between Caucasians and Ghanaians in the gene encoding the synthesis of the P-450 isozyme involved in polymorphic sparteine oxidation.
在154名无亲缘关系的加纳受试者中研究了鹰爪豆碱氧化作用，该作用在不同白种人群体中表现出遗传多态性。鹰爪豆碱、2-脱氢鹰爪豆碱和5-脱氢鹰爪豆碱的尿中总回收率（占给药剂量的56.6±16.6%）与白种人无差异。与白种人不同，白种人群体中有6.3%至9%的人是慢代谢者（PM），而在加纳人群样本中未观察到慢代谢者。这些数据似乎表明，在编码参与多态性鹰爪豆碱氧化的P-450同工酶合成的基因中，白种人和加纳人之间存在等位基因差异。
