大鼠肝脏苯丙氨酸羟化酶。一种测量活性的方法，特别提及该酶和蝶啶辅因子的独特特征。 - Suppr

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超能文献

Rat liver phenylalanine hydroxylase. A method for the measurement of activity, with particular reference to the distinctive features of the enzyme and the pteridine cofactor.

作者信息

Nielsen K H

出版信息

Eur J Biochem. 1969 Jan;7(3):360-9. doi: 10.1111/j.1432-1033.1969.tb19617.x.

DOI:10.1111/j.1432-1033.1969.tb19617.x

PMID:5791581

Abstract

摘要

相似文献

Rat liver phenylalanine hydroxylase. A method for the measurement of activity, with particular reference to the distinctive features of the enzyme and the pteridine cofactor.大鼠肝脏苯丙氨酸羟化酶。一种测量活性的方法，特别提及该酶和蝶啶辅因子的独特特征。

Eur J Biochem. 1969 Jan;7(3):360-9. doi: 10.1111/j.1432-1033.1969.tb19617.x.

The inactivation of phenylalanine hydroxylase by 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine and the aerobic oxidation of the latter. The effects of catalase, dithiothreitol and reduced nicotinamide-adenine dinucleotide.2-氨基-4-羟基-6,7-二甲基四氢蝶啶对苯丙氨酸羟化酶的失活作用及其需氧氧化。过氧化氢酶、二硫苏糖醇和还原型烟酰胺腺嘌呤二核苷酸的影响。

Biochem J. 1971 Nov;125(2):563-8. doi: 10.1042/bj1250563.

Phenylalanine hydroxylase of Macaca irus. Purification of two components of the enzyme.

Biochim Biophys Acta. 1971 Apr 14;235(1):61-72. doi: 10.1016/0005-2744(71)90033-7.

Cofactor requirements of gamma-butyrobetaine hydroxylase from rat liver.大鼠肝脏γ-丁甜菜碱羟化酶的辅因子需求

J Biol Chem. 1970 Aug 25;245(16):4178-86.

Two mechanisms for the inhibition in vitro of phenylalanine hydroxylase by catecholamines.儿茶酚胺在体外对苯丙氨酸羟化酶的两种抑制机制。

Biochem Pharmacol. 1971 Oct;20(10):2543-53. doi: 10.1016/0006-2952(71)90162-6.

Phenylalanine hydroxylase activity towards two substrates simultaneously: enhancement of inhibition by phenylalanine, tryptophan and their derivatives.苯丙氨酸羟化酶对两种底物的同时活性：苯丙氨酸、色氨酸及其衍生物对抑制作用的增强。

Biochim Biophys Acta. 1968 Aug 27;167(1):99-109. doi: 10.1016/0005-2744(68)90280-5.

Stimulation of rat liver phenylalanine hydroxylase activity by derivatives of vitamin E.维生素E衍生物对大鼠肝脏苯丙氨酸羟化酶活性的刺激作用。

Biochem Biophys Res Commun. 1972 Sep 5;48(5):1185-91. doi: 10.1016/0006-291x(72)90836-4.

A direct assay for liver phenylalanine hydroxylase.一种肝脏苯丙氨酸羟化酶的直接检测方法。

Biochim Biophys Acta. 1969 Nov 4;191(2):249-56. doi: 10.1016/0005-2744(69)90244-7.

The effect of variation of cofactor and substrate structure on the action of phenylalanine hydroxylase.

Biochem Biophys Res Commun. 1968 Sep 6;32(5):788-93. doi: 10.1016/0006-291x(68)90309-4.

Activation of phenylalanine hydroxylase by phenylalanine.苯丙氨酸对苯丙氨酸羟化酶的激活作用。

Biochim Biophys Acta. 1971 Aug 20;242(2):345-54. doi: 10.1016/0005-2744(71)90226-9.

引用本文的文献

Acetylation of Phenylalanine Hydroxylase and Tryptophan 2,3-Dioxygenase Alters Hepatic Aromatic Amino Acid Metabolism in Weaned Piglets.苯丙氨酸羟化酶和色氨酸2,3-双加氧酶的乙酰化改变断奶仔猪肝脏芳香族氨基酸代谢。

Metabolites. 2020 Apr 9;10(4):146. doi: 10.3390/metabo10040146.

Substituting Tyr in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation.替换人苯丙氨酸羟化酶活性位点环中的酪氨酸会影响催化作用和底物激活。

FEBS Open Bio. 2017 Jun 12;7(7):1026-1036. doi: 10.1002/2211-5463.12243. eCollection 2017 Jul.

Kinetic mechanism of phenylalanine hydroxylase: intrinsic binding and rate constants from single-turnover experiments.苯丙氨酸羟化酶的动力学机制：单次反应实验的固有结合和速率常数。

Biochemistry. 2013 Feb 12;52(6):1062-73. doi: 10.1021/bi301675e. Epub 2013 Jan 29.

Allosteric regulation of phenylalanine hydroxylase.苯丙氨酸羟化酶的别构调节。

Arch Biochem Biophys. 2012 Mar 15;519(2):194-201. doi: 10.1016/j.abb.2011.09.012. Epub 2011 Oct 7.

The role of phenylalanine in structure-function relationships of phenylalanine hydroxylase revealed by radiation target analysis.通过辐射靶分析揭示苯丙氨酸在苯丙氨酸羟化酶结构-功能关系中的作用。

Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):491-5. doi: 10.1073/pnas.94.2.491.

Further studies of the role of Ser-16 in the regulation of the activity of phenylalanine hydroxylase.关于丝氨酸-16在苯丙氨酸羟化酶活性调节中作用的进一步研究。

Proc Natl Acad Sci U S A. 1995 May 23;92(11):4743-7. doi: 10.1073/pnas.92.11.4743.

Comparative studies of four monoclonal antibodies to phenylalanine hydroxylase exhibiting different properties with respect to substrate-dependence, species-specificity and a range of effects on enzyme activity.对四种苯丙氨酸羟化酶单克隆抗体进行的比较研究，这些抗体在底物依赖性、物种特异性以及对酶活性的一系列影响方面表现出不同特性。

Biochem J. 1981 Dec 1;199(3):527-35. doi: 10.1042/bj1990527.

Dihydropteridine reductase: implication on the regulation of catecholamine biosynthesis.二氢蝶啶还原酶：对儿茶酚胺生物合成调节的影响

Proc Natl Acad Sci U S A. 1971 Sep;68(9):2087-91. doi: 10.1073/pnas.68.9.2087.

The quantitative determination of phenylalanine hydroxylase in rat tissues. Its developmental formation in liver.大鼠组织中苯丙氨酸羟化酶的定量测定。其在肝脏中的发育形成。

Biochem J. 1972 May;127(4):669-74. doi: 10.1042/bj1270669.

The effect of L-ascorbate on catecholamine biosynthesis.L-抗坏血酸盐对儿茶酚胺生物合成的影响。

Biochem J. 1973 Mar;131(3):611-3. doi: 10.1042/bj1310611.

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