苯丙氨酸羟化酶的别构调节。
Allosteric regulation of phenylalanine hydroxylase.
机构信息
Department of Biochemistry and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, TX 78229-3900, USA.
出版信息
Arch Biochem Biophys. 2012 Mar 15;519(2):194-201. doi: 10.1016/j.abb.2011.09.012. Epub 2011 Oct 7.
Abstract
The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin. Phosphorylation of Ser16 lowers the concentration of phenylalanine for activation. This review discusses the present understanding of the molecular details of the allosteric regulation of the enzyme.
摘要
肝脏酶苯丙氨酸羟化酶负责将饮食中过量的苯丙氨酸转化为酪氨酸。苯丙氨酸羟化酶被苯丙氨酸激活；这种激活被生理还原底物四氢生物蝶呤抑制。丝氨酸 16 的磷酸化降低了苯丙氨酸的激活浓度。这篇综述讨论了目前对该酶变构调节的分子细节的理解。
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