Stone K J, Townsley B H
Biochem J. 1973 Mar;131(3):611-3. doi: 10.1042/bj1310611.
l-Ascorbate stimulates the enzymic hydroxylation of phenylalanine in vitro by recycling tetrahydrobiopterin, which reduces O(2) utilized in the reaction. It is suggested that ascorbate might have a similar function in vivo; this would explain the apparent regulation of tyrosine hydroxylase and tryptophan hydroxylase activities by this vitamin.
左旋抗坏血酸通过循环利用四氢生物蝶呤在体外刺激苯丙氨酸的酶促羟化反应,四氢生物蝶呤可减少该反应中消耗的氧气。有人提出抗坏血酸在体内可能具有类似功能;这将解释该维生素对酪氨酸羟化酶和色氨酸羟化酶活性的明显调节作用。