Myerburg R J, Briese F W, Conde C, Mallon S M, Liberthson R R, Castellanos A
JAMA. 1977 Dec 12;238(24):2621-4.
Ambulatory rhythm monitoring and chronic arrhythmia management were studied in 16 patients resuscitated from prehospital cardiac arrest. Asymptomatic complex ventricular arrhythmias (ACVA) occurred in 12 patients (75%) entering long-term follow-up during the first 12 months (average follow-up, 13.25 months). The patients' therapy consisted of a dose-adjusted, membrane-active antiarrhythmic drug regimen monitored by blood levels. While there has been little change in the frequency of ACVAs despite carefully controlled antiarrhythmic management, only one death has occurred during 212 patient-months of postarrest follow-up, a 6% one-year mortality. This compares favorably to our previous experience in survivors of prehospital cardiac arrest not receiving a controlled antiarrhythmic program. Despite the failure to suppress ACVAs, the drug-monitored population is showing a trend toward a decreased frequency of recurrent cardiac arrest.
对16例从院外心脏骤停中复苏的患者进行了动态心律监测和慢性心律失常管理研究。在进入为期12个月长期随访（平均随访13.25个月）的12例患者（75%）中出现了无症状复杂性室性心律失常（ACVA）。患者的治疗方案包括根据血药浓度调整剂量的膜活性抗心律失常药物方案。尽管在精心控制抗心律失常治疗的情况下ACVA的发生频率几乎没有变化，但在心脏骤停后随访的212患者月中仅发生1例死亡，一年死亡率为6%。这与我们之前在未接受控制性抗心律失常方案的院外心脏骤停幸存者中的经验相比具有优势。尽管未能抑制ACVA，但药物监测人群的心脏骤停复发频率呈下降趋势。
