Jacquet P
Arch Pathol Lab Med. 1977 Dec;101(12):641-3.
The development of the embryo until day 7 was studied in histologic sections of the uterus, oviduct, and ovary from normal and lead-treated mice (0.5% of lead in the diet). Such lead treatment causes a substantial reduction in pregnancies in successfully mated female mice. After lead treatment, the blastocyst is formed normally, although it has a slightly reduced size. Differentiation of giant cells in the trophoblast and of decidua cells in the uterus is, however, impaired. Moreover, the corpora lutea are underdeveloped. Since earlier normal estradiol secretion on day 4 and a diminished progesterone secretion from day 5 on had been found, activation of the embryo and/or development of decidua cells fall due to the absence of this hormone.
在正常小鼠和铅处理小鼠（饮食中含0.5%铅）的子宫、输卵管和卵巢组织切片中，研究了胚胎直至第7天的发育情况。这种铅处理会导致成功交配的雌性小鼠怀孕率大幅降低。铅处理后，胚泡正常形成，不过其大小略有减小。然而，滋养层中巨细胞和子宫中蜕膜细胞的分化受损。此外，黄体发育不全。由于此前已发现第4天雌二醇分泌正常，而从第5天起孕酮分泌减少，胚胎的激活和/或蜕膜细胞的发育因缺乏这种激素而受到影响。
