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小鼠着床前期胚胎对无机铅的敏感性差异

Differential susceptibility of the embryo to inorganic lead during periimplantation in the mouse.

作者信息

Wide M, Nilsson O

出版信息

Teratology. 1977 Dec;16(3):273-6. doi: 10.1002/tera.1420160305.

DOI:10.1002/tera.1420160305
PMID:594910
Abstract

The effect of intravenously administered inorganic lead on periimplantation period of embryonic development in the mouse was investigated with light microscopy. Three developmental stages were studied: the attachment of the blastocyst, the invasion of the trophoblast and the formation of the primitive streak. All three stages were affected, but the stage of invasion was found to be the most susceptible to lead as determined by decrease in frequency of animals with normal embryos.

摘要

采用光学显微镜研究了静脉注射无机铅对小鼠胚胎着床期发育的影响。研究了三个发育阶段:胚泡附着、滋养层侵入和原条形成。所有三个阶段均受到影响,但通过正常胚胎动物频率的降低确定,侵入阶段被发现对铅最为敏感。

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