Teien A N
Thromb Haemost. 1977 Oct 31;38(3):701-6.
Heparin (100 U/kg body-weight) was injected intravenously, and heparin concentration in plasma determined by polybrene titration. Mean heparin half-life was 117.8 min in a group of patients with liver cirrhosis and normal renal function (n = 6) as compared to 74.0 min in the normal group (n = 6). The difference between the two groups is statistically significant (p approximately 0.02). Heparin half-life was correlated to galactose half-life in the patients (r=0.83, p= 0.05). The findings suggest that heparin is metabolized in the liver. There was a significant fall in antithrombin III activities in the normals, but not in the patients. A possible explanation may be that the normal liver removes heparin bound to antithrombin III, and that this function is impaired in liver cirrhosis.
静脉注射肝素（100 U/kg体重），通过鱼精蛋白滴定法测定血浆中的肝素浓度。一组肝硬化且肾功能正常的患者（n = 6）的平均肝素半衰期为117.8分钟，而正常组（n = 6）为74.0分钟。两组之间的差异具有统计学意义（p约为0.02）。患者的肝素半衰期与半乳糖半衰期相关（r = 0.83，p = 0.05）。这些发现表明肝素在肝脏中代谢。正常组抗凝血酶III活性显著下降，但患者组未出现这种情况。一种可能的解释是，正常肝脏会清除与抗凝血酶III结合的肝素，而肝硬化时这种功能受损。
