Teien A N, Bjoornson J
Scand J Haematol. 1976 Jul;17(1):29-35.
Heparin (100 U/kg bodyweight) was administered as single i.v. injections, and heparin concentration in plasma determined by polybrene titration. Mean concentration half-life was 74.7 min in the normal group (n = 6), 118.6 min in the nephrectomized patients (n = 5), and 97.8 min in the other uraemic patients (n = 6). The differences between the mean values for the normals and for the 2 patient groups were statistically significant (p is less than 0.001 and p approximately 0.2 respectively). Mean anticoagulant half-life (based on thrombin clotting time) was 64.3, 75.8 and 62.7 min in the 3 groups. The differences between heparin concentration half-life and anticoagulant half-life in the 3 groups were statistically significant. These differences may be partly explained by a significant fall in heparin cofactor activity after injection of heparin. There was a strong positive individual correlation between heparin concentration half-life and anticoagulant half-life in the patients (r = 0.94), but not in the normal group (r = 0.31). There was a strong negative individual correlation between heparin tolerance and heparin concentration half-life in the patients (r = -0.84), but no correlation in the normal group. It is concluded that severely impaired renal function has a significant, but moderate influence on heparin elimination.
以每千克体重100单位静脉注射给予肝素，通过鱼精蛋白滴定法测定血浆中的肝素浓度。正常组（n = 6）的平均浓度半衰期为74.7分钟，肾切除患者（n = 5）为118.6分钟，其他尿毒症患者（n = 6）为97.8分钟。正常组与两组患者的平均值之间的差异具有统计学意义（分别为p < 0.001和p ≈ 0.2）。三组的平均抗凝半衰期（基于凝血酶凝血时间）分别为64.3、75.8和62.7分钟。三组中肝素浓度半衰期与抗凝半衰期之间的差异具有统计学意义。这些差异可能部分是由于注射肝素后肝素辅因子活性显著下降所致。患者中肝素浓度半衰期与抗凝半衰期之间存在强正相关（r = 0.94），但正常组中无此相关性（r = 0.31）。患者中肝素耐受性与肝素浓度半衰期之间存在强负相关（r = -0.84），但正常组中无相关性。结论是，严重受损的肾功能对肝素清除有显著但中等程度的影响。
