妊娠子痫前期的纤维蛋白溶解作用。
Fibrinolysis in pre-eclamptic toxaemia of pregnancy.
作者信息
Wardle E N, Menon I S
出版信息
Br Med J. 1969 Jun 7;2(5657):625-7. doi: 10.1136/bmj.2.5657.625.
Abstract
Plasma fibrinolysis is much reduced in normal pregnancy but is the same in women with toxaemia or hypertension, though urinary fibrinolysis is lower in them. The evidence suggests that in toxaemia there must be in addition a slow state of intravascular coagulation. Fibrinolytic inhibitors were found to be normal in this series, though in pregnancy there are raised levels of antitrypsin, alpha(2)-macroglobulin, and beta-lipoprotein. beta-Lipoprotein levels in non-pregnant patients show a correlation with euglobulin lysis times and with inhibitor units.
摘要
正常妊娠时血浆纤维蛋白溶解作用明显降低，但患有毒血症或高血压的女性其血浆纤维蛋白溶解作用则无变化，不过她们的尿液纤维蛋白溶解作用较低。有证据表明，毒血症患者体内必定还存在血管内凝血的缓慢状态。在该系列研究中发现纤维蛋白溶解抑制剂正常，尽管在妊娠期间抗胰蛋白酶、α2-巨球蛋白和β-脂蛋白的水平会升高。非妊娠患者的β-脂蛋白水平与优球蛋白溶解时间及抑制剂单位呈相关性。
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