Chen Minhua, Ruan Wei, Zhang Lingling, Hu Bangchuan, Yang Xianghong
Department of Critical Care Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
Department of Communicable Diseases of Control and Prevention, Zhejiang Provincial Centre for Disease Control and Prevention, Hangzhou 310000, Zhejiang, China.
Korean J Parasitol. 2019 Jun;57(3):291-294. doi: 10.3347/kjp.2019.57.3.291. Epub 2019 Jun 30.
Primary amebic encephalitis (PAM) is a devastating central nervous system infection caused by Naegleria fowleri, a free-living amoeba, which can survive in soil and warm fresh water. Here, a 43-year-old healthy male was exposed to warm freshwater 5 days before the symptom onset. He rapidly developed severe cerebral edema before the diagnosis of PAM and was treated with intravenous conventional amphotericin B while died of terminal cerebral hernia finally. Comparing the patients with PAM who has similar clinical symptoms to those with other common types of meningoencephalitis, this infection is probably curable if treated early and aggressively. PAM should be considered in the differential diagnosis of purulent meningoencephalitis, especially in patients with recent freshwater-related activities during the hot season.
原发性阿米巴脑炎（PAM）是一种由福氏耐格里阿米巴引起的毁灭性中枢神经系统感染，福氏耐格里阿米巴是一种自由生活的变形虫，可在土壤和温暖的淡水中生存。在此，一名43岁的健康男性在症状出现前5天接触了温暖的淡水。他在PAM诊断前迅速出现严重脑水肿，并接受了静脉注射常规两性霉素B治疗，但最终死于晚期脑疝。将具有相似临床症状的PAM患者与其他常见类型的脑膜脑炎患者进行比较，如果早期积极治疗，这种感染可能是可治愈的。在化脓性脑膜脑炎的鉴别诊断中应考虑PAM，尤其是在炎热季节近期有与淡水相关活动的患者中。
