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Metabolic activation of diethylstilbestrol and aminostilbene-derivatives.

作者信息

Neumann H G, Metzler M, Töpner W

出版信息

Arch Toxicol. 1977 Dec 30;39(1-2):21-30. doi: 10.1007/BF00343272.

DOI:10.1007/BF00343272
PMID:579979
Abstract

Diethylstilbestrol and trans-4-dimethylaminostilbene are metabolically activated and several of their metabolites are able to react with cellular macromolecules. Some of the problems are discussed which are encountered in linking a particular metabolite with the mutagenic and carcinogenic properties of these compounds.

摘要

相似文献

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Metabolic activation of diethylstilbestrol and aminostilbene-derivatives.
Arch Toxicol. 1977 Dec 30;39(1-2):21-30. doi: 10.1007/BF00343272.
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Proceedings: The metabolic activation of the double bond of carcinogenic stilbenes.
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Analysis of hemoglobin as a dose monitor for alkylating and arylating agents.

本文引用的文献

1
Metabolic epoxidation of trans-4-acetylaminostilbene: a protective mechanism against its activation to a mutagen.
Biochem Biophys Res Commun. 1976 Dec 20;73(4):1025-9. doi: 10.1016/0006-291x(76)90225-4.
2
The enzymatic reduction of the N-hydroxy derivatives of 2-acetylaminofluorene and related carcinogens by tissue preparations.组织制剂对2-乙酰氨基芴及相关致癌物的N-羟基衍生物的酶促还原作用。
Cancer Res. 1965 Nov;25(10):1743-52.
3
Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women.阴道腺癌。年轻女性母亲接受己烯雌酚治疗与肿瘤出现的关联。
血红蛋白作为烷化剂和芳基化剂剂量监测指标的分析
Arch Toxicol. 1984 Nov;56(1):1-6. doi: 10.1007/BF00316343.
4
Blood protein conjugates and acetylation of aromatic amines. New findings on biological monitoring.血液蛋白结合物与芳香胺的乙酰化作用。生物监测的新发现。
Int Arch Occup Environ Health. 1985;56(3):179-96. doi: 10.1007/BF00396596.
5
Biomonitoring of aromatic amines and alkylating agents by measuring hemoglobin adducts.通过测量血红蛋白加合物对芳香胺和烷基化剂进行生物监测。
Int Arch Occup Environ Health. 1988;60(3):151-5. doi: 10.1007/BF00378690.
N Engl J Med. 1971 Apr 22;284(15):878-81. doi: 10.1056/NEJM197104222841604.
4
N-acetoxy-N-acetylaminoarenes and nitrosoarenes. One-electron non-enzymatic and enzymatic oxidation products of various carcinogenic aromatic acethydroxamic acids.N-乙酰氧基-N-乙酰氨基芳烃和亚硝基芳烃。各种致癌芳香族乙酰氧肟酸的单电子非酶促和酶促氧化产物。
Biochim Biophys Acta. 1972 Jun 26;273(1):40-51. doi: 10.1016/0304-4165(72)90189-4.
5
The relevance of chemico-biological interactions for the toxic and carcinogenic effects of aromatic amines. V. The pharmacokinetics of related aromatic amines in blood.
Chem Biol Interact. 1972 May;4(6):409-19. doi: 10.1016/0009-2797(72)90061-0.
6
Methylmercapto-4-acetylaminostilbenes as products of the reaction of n-acetoxy-4-acetylaminostilbene with methionine and as degradation products of liver protein from rats given n-hydroxy-4-acetylaminostilbene.甲硫基-4-乙酰氨基芪作为N-乙酰氧基-4-乙酰氨基芪与蛋氨酸反应的产物以及给予N-羟基-4-乙酰氨基芪的大鼠肝脏蛋白质的降解产物。
Cancer Res. 1974 Sep;34(9):2232-9.
7
Mechanism of reaction, tissue distribution, and inhibition of arylhydroxamic acid acyltransferase.
Cancer Res. 1974 Jun;34(6):1503-15.
8
Electrophilic N-acetoxyaminoarenes derived from carcinogenic N-hydroxy-N-acetylaminoarenes by enzymatic deacetylation and transacetylation in liver.亲电N-乙酰氧基氨基芳烃是由致癌性N-羟基-N-乙酰氨基芳烃在肝脏中通过酶促脱乙酰化和转乙酰化作用衍生而来的。
Biochim Biophys Acta. 1972 Dec 29;286(2):272-98. doi: 10.1016/0304-4165(72)90265-6.
9
Clear-cell adenocarcinoma of the genital tract in young females. Registry report.年轻女性生殖道透明细胞腺癌。登记报告。
N Engl J Med. 1972 Dec 21;287(25):1259-64. doi: 10.1056/NEJM197212212872501.
10
Carcinogenesis by aromatic amines.芳香胺致癌作用
Biochim Biophys Acta. 1974 Sep 9;355(2):177-203. doi: 10.1016/0304-419x(74)90003-1.