Szabó V G, Magyar Z
Zentralinstitut für Traumatologie, Budapest, Ungarn.
Arzneimittelforschung. 1977;27(12):2332-5.
The effect of benzopyrones on edema formation in acute thrombophlebitis was investigated in dogs. Thrombophlebitis was produced by the ligation of the femoral vein and the injection of turpentine oil. The benzopyrones delayed edema formation and sped its regression. Protein concentration in lymph and tissue fluid of the edematous extremity was not significantly higher than in the same fluids of the intact limb, and no significant differences were observed in lymphatic and tissue fluid protein concentrations between the treated and untreated animals. It is concluded that the benzopyrones have their main effect on edema in acute thrombophlebitis by causing proteolysis and enhancing the removal of protein from the tissue fluid.
在犬类中研究了苯并吡喃对急性血栓性静脉炎中水肿形成的影响。通过结扎股静脉并注射松节油来诱发血栓性静脉炎。苯并吡喃可延迟水肿形成并加速其消退。水肿肢体的淋巴液和组织液中的蛋白质浓度并不显著高于正常肢体相同液体中的蛋白质浓度，且在治疗组和未治疗组动物之间，淋巴液和组织液蛋白质浓度未观察到显著差异。得出的结论是，苯并吡喃对急性血栓性静脉炎水肿的主要作用是通过引起蛋白水解并增强从组织液中清除蛋白质来实现的。
