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9 Studies of lymphocyte transport are reported in which the 51Cr labelling technique of Hersey (1971) was employed on 8 patients with chronic lymphocytic leukaemia (CLL) and 1 with lymphosarcoma. 2. A new approach to the analysis of the data was formulated employing the principles of impulse analysis. This allowed the quantitation of cell transport between various locations making the minimum number of assumptions. It was also possible to take account of the principal defect of this label, its tendency to elute from live cells. 3. In spite of marked lymphocytosis, numbers of cells moving between those tissues whose lymphocytes exchange relatively slowly and the bloodstream was found to be normal. The blood and lymph nodes may therefore accumulate lymphocytes in response to a transport defect which hinders the progress of these cells from one pool to another. 4. The finding that CLL lymphocytes fluxes are normal in certain locations casts doubt on the hypothesis that lymphocyte proliferation is uncontrolled in this disease. An alternative possibility is that cell proliferation is regulated so as to maintain these fluxes within the normal range.

报告了9项淋巴细胞转运研究，其中采用了赫西（1971年）的51铬标记技术，研究对象为8例慢性淋巴细胞白血病（CLL）患者和1例淋巴肉瘤患者。
运用脉冲分析原理制定了一种新的数据分析法。这使得在做出最少假设的情况下，能够对不同位置之间的细胞转运进行定量分析。同时也能够考虑到这种标记的主要缺陷，即其从活细胞中洗脱的倾向。
尽管存在明显的淋巴细胞增多，但发现淋巴细胞交换相对缓慢的组织与血液之间移动的细胞数量正常。因此，血液和淋巴结可能会因转运缺陷而积聚淋巴细胞，这种缺陷阻碍了这些细胞从一个池转移到另一个池。
CLL淋巴细胞在某些位置通量正常这一发现，对该疾病中淋巴细胞增殖不受控制这一假说提出了质疑。另一种可能性是，细胞增殖受到调节，以便将这些通量维持在正常范围内。

9 Studies of lymphocyte transport are reported in which the 51Cr labelling technique of Hersey (1971) was employed on 8 patients with chronic lymphocytic leukaemia (CLL) and 1 with lymphosarcoma. 2. A new approach to the analysis of the data was formulated employing the principles of impulse analysis. This allowed the quantitation of cell transport between various locations making the minimum number of assumptions. It was also possible to take account of the principal defect of this label, its tendency to elute from live cells. 3. In spite of marked lymphocytosis, numbers of cells moving between those tissues whose lymphocytes exchange relatively slowly and the bloodstream was found to be normal. The blood and lymph nodes may therefore accumulate lymphocytes in response to a transport defect which hinders the progress of these cells from one pool to another. 4. The finding that CLL lymphocytes fluxes are normal in certain locations casts doubt on the hypothesis that lymphocyte proliferation is uncontrolled in this disease. An alternative possibility is that cell proliferation is regulated so as to maintain these fluxes within the normal range.

报告了9项淋巴细胞转运研究，其中采用了赫西（1971年）的51铬标记技术，研究对象为8例慢性淋巴细胞白血病（CLL）患者和1例淋巴肉瘤患者。
运用脉冲分析原理制定了一种新的数据分析法。这使得在做出最少假设的情况下，能够对不同位置之间的细胞转运进行定量分析。同时也能够考虑到这种标记的主要缺陷，即其从活细胞中洗脱的倾向。
尽管存在明显的淋巴细胞增多，但发现淋巴细胞交换相对缓慢的组织与血液之间移动的细胞数量正常。因此，血液和淋巴结可能会因转运缺陷而积聚淋巴细胞，这种缺陷阻碍了这些细胞从一个池转移到另一个池。
CLL淋巴细胞在某些位置通量正常这一发现，对该疾病中淋巴细胞增殖不受控制这一假说提出了质疑。另一种可能性是，细胞增殖受到调节，以便将这些通量维持在正常范围内。

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