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大鼠吸入铬酸锌后全血铬水平及铬排泄情况

Whole blood chromium level and chromium excretion in the rat after zinc chromate inhalation.

作者信息

Langård S, Gundersen N, Tsalev D L, Gylseth B

出版信息

Acta Pharmacol Toxicol (Copenh). 1978 Feb;42(2):142-9. doi: 10.1111/j.1600-0773.1978.tb02182.x.

DOI:10.1111/j.1600-0773.1978.tb02182.x
PMID:580157
Abstract

Studies on absorption and excretion of chromium in the rat exposed to known atmospheric concentrations of zinc chromate in an inhalation chamber and the influence of diurnal variations in physical activity have been carried out. Chromium analyses were performed on samples of blood, urine and faeces using a method for determining chromium in small samples of biological material based on flameless atomic absorption spectrometry. Zinc chromate is absorbed quickly during exposure and excreted mainly via urine. An accumulation of chromium in blood was observed, followed by a slow elimination. It is suggested that chromium from zinc chromate enters the blood in the hexavalent state.

摘要

对暴露于吸入室内已知大气浓度铬酸锌的大鼠体内铬的吸收和排泄,以及身体活动昼夜变化的影响进行了研究。采用基于无火焰原子吸收光谱法的生物材料小样本中铬的测定方法,对血液、尿液和粪便样本进行了铬分析。铬酸锌在暴露期间迅速被吸收,主要通过尿液排泄。观察到血液中铬的积累,随后缓慢消除。有人认为,铬酸锌中的铬以六价状态进入血液。

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Monitoring of chromium and nickel in biological fluids of stainless steel welders using the flux-cored-wire (FCW) welding method.
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Int Arch Occup Environ Health. 2004 Nov;77(8):587-91. doi: 10.1007/s00420-004-0560-z. Epub 2004 Nov 6.
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Hair chromium concentration and chromium excretion in tannery workers.制革工人头发中的铬浓度及铬排泄情况
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