Flexner J B, Flexner L B
Science. 1969 Sep 12;165(3898):1143-4. doi: 10.1126/science.165.3898.1143.
Puromycin dihydrochloride neutralized with bases of potassium, lithium, calcium, or magnesium fails to block expression of memory of maze learning in mice, unlike puromycin neutralized with NaOH. This failure may be due to cationic binding at anionic membrane sites with a resultant exclusion of sufficient peptidyl-puromycin to make it ineffective in blocking memory.
与用氢氧化钠中和的嘌呤霉素不同，用钾、锂、钙或镁的碱中和的盐酸嘌呤霉素不能阻断小鼠迷宫学习记忆的表达。这种失败可能是由于阳离子与阴离子膜位点结合，导致足够的肽基嘌呤霉素被排除，从而使其在阻断记忆方面无效。
