垂体肽与嘌呤霉素对记忆的抑制作用。
Pituitary peptides and the suppression of memory by puromycin.
作者信息
Flexner J B, Flexner L B
出版信息
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2519-21. doi: 10.1073/pnas.68.10.2519.
Abstract
It has previously been shown that the expression of memory of maze-learning in mice is blocked by intracerebrally-injected puromycin one or more days after the training experience, and that bilateral adrenalectomy before training protects memory against this effect of puromycin. Purified cortrophin gel, injected subcutaneously up to 3 days before training, has now been found to give results like those obtained with adrenalectomy and, additionally, to provide a high degree of protection when injected up to 16 hr after training. Several possible explanations for these effects have been considered and found to be inadequate.
摘要
先前已经表明，在训练经历后的一天或多天，脑内注射嘌呤霉素会阻断小鼠迷宫学习记忆的表达，并且训练前双侧肾上腺切除术可保护记忆免受嘌呤霉素这种作用的影响。现已发现，在训练前3天皮下注射纯化的促肾上腺皮质激素凝胶，其结果与肾上腺切除术的结果相似，此外，在训练后16小时内注射也能提供高度保护。已经考虑了对这些效应的几种可能解释，但发现并不充分。
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